Research

The International Spine Study Group works to consistently put forward high quality, meaningful research. The findings are shared via podium presentations, posters, and published manuscripts. Explore recent presentations and all publications from the ISSG here.

https://issgf.org/images/uploads/images/ISSG_Publications_2009-2019.pdf

2020 Journal Publications (N=38)

1. Passias P.G., Segreto F.A., Horn S.R., Lafage V., Lafage R., Smith J.S., Naessig S., Bortz C., Klineberg E.O., Diebo B.G., Sciubba D.M., Neuman B.J., Hamilton D.K., Burton D.C., Hart R.A., Schwab F.J., Bess S., Shaffrey C.I., Nunley P., Ames C.P., International Spine Study Group. Fatty infiltration of the cervical extensor musculature, cervical sagittal balance, and clinical outcomes: An analysis of operative adult cervical deformity patients. Journal of Clinical Neuroscience. 2020
2. Bortz C., Passias P.G., Pierce K.E., Alas H., Brown A., Naessig S., Ahmad W., Lafage R., Ames C.P., Diebo B.G., Line B.G., Klineberg E.O., Burton D.C., Eastlack R.K., Kim H.J., Sciubba D.M., Soroceanu A., Bess S., Shaffrey C.I., Schwab F.J., Smith J.S., Lafage V.. Radiographic benefit of incorporating the inflection between the cervical and thoracic curves in fusion constructs for surgical cervical deformity patients. Journal of Craniovertebral Junction and Spine. 2020
3. Daniels A.H., Reid D.B., Durand W.M., Hamilton D.K., Passias P.G., Kim H.J., Protopsaltis T.S., Lafage V., Smith J.S., Shaffrey C.I., Gupta M., Klineberg E., Schwab F., Burton D., Bess S., Ames C.P., Hart R.A.. Upper-thoracic versus lower-thoracic upper instrumented vertebra in adult spinal deformity patients undergoing fusion to the pelvis: Surgical decision-making and patient outcomes. Journal of Neurosurgery: Spine. 2020
4. Kim H.J., Virk S., Elysee J., Passias P., Ames C., Shaffrey C.I., Mundis G., Jr., Protopsaltis T., Gupta M., Klineberg E., Smith J.S., Burton D., Schwab F., Lafage V., Lafage R., and the International Spine Study Group. The morphology of cervical deformities: A two-step cluster analysis to identify cervical deformity patterns. Journal of Neurosurgery: Spine. 2020
5. Mummaneni P.V., Park P., Shaffrey C.I., Wang M.Y., Uribe J.S., Fessler R.G., Chou D., Kanter A.S., Okonkwo D.O., Mundis G.M., Jr., Eastlack R.K., Nunley P.D., Anand N., Virk M.S., Lenke L.G., Than K.D., Robinson L.C., Fu K.-M., the International Spine Study Group (ISSG). The MISDEF2 algorithm: An updated algorithm for patient selection in minimally invasive deformity surgery. Journal of Neurosurgery: Spine. 2020
6. Horn S.R., Passias P.G., Oh C., Lafage V., Lafage R., Smith J.S., Line B., Anand N., Segreto F.A., Bortz C.A., Scheer J.K., Eastlack R.K., Deviren V., Mummaneni P.V., Daniels A.H., Park P., Nunley P.D., Kim H.J., Klineberg E.O., Burton D.C., Hart R.A., Schwab F.J., Bess S., Shaffrey C.I., Ames C.P., the International Spine Study Group. Predicting the combined occurrence of poor clinical and radiographic outcomes following cervical deformity corrective surgery. Journal of Neurosurgery: Spine. 2020
7. Lafage R., Beyer G., Schwab F., Klineberg E., Burton D., Bess S., Kim H.J., Smith J., Ames C., Hostin R., Khalife M., Shaffrey C., Mundis G., Lafage V.. Risk Factor Analysis for Proximal Junctional Kyphosis After Adult Spinal Deformity Surgery: A New Simple Scoring System to Identify High-Risk Patients. Global Spine Journal. 2020
8. Yagi M., Ames C.P., Hosogane N., Smith J.S., Shaffrey C.I., Schwab F., Lafage V., Bess S., Matsumoto M., Watanabe K., International Spine Study Group (ISSG). Lower Satisfaction After Adult Spinal Deformity Surgery in Japan Than in the United States Despite Similar SRS-22 Pain and Function Scores: A Propensity-Score Matched Analysis. Spine. 2020
9. Durand W.M., Daniels A.H., Hamilton D.K., Passias P., Kim H.J., Protopsaltis T., LaFage V., Smith J.S., Shaffrey C., Gupta M., Klineberg E., Schwab F., Burton D., Bess S., Ames C., Hart R., International Spine Study Group. Artificial Intelligence Models Predict Operative Versus Nonoperative Management of Patients with Adult Spinal Deformity with 86% Accuracy. World Neurosurgery. 2020
10. Durand W.M., Daniels A.H., Hamilton D.K., Passias P., Kim H.J., Protopsaltis T., LaFage V., Smith J.S., Shaffrey C., Gupta M., Kelly M.P., Klineberg E., Schwab F., Burton D., Bess S., Ames C., Hart R., International Spine Study Group (ISSG). The spino-pelvic ratio: a novel global sagittal parameter associated with clinical outcomes in adult spinal deformity patients. European Spine Journal. 2020
11. Ogura Y., Gum J.L., Hostin R.A., Robinson C., Ames C.P., Glassman S.D., Burton D.C., Bess R.S., Shaffrey C.I., Smith J.S., Yeramaneni S., Lafage V.F., Protopsaltis T., Passias P.G., Schwab F.J., Carreon L.Y., International Spine Study Group (ISSG). Cost-effectiveness of surgical treatment of adult spinal deformity: comparison of posterior-only versus anteroposterior approach. Spine Journal. 2020
12. Line B., Bess S., Lafage V., Ames C., Burton D., Kim H.J., Gupta M., Hart R., Klineberg E., Kelly M., Kebaish K., Hostin R., Mundis G., Schwab F., Shaffrey C., Smith J.S.. Counseling Guidelines for Anticipated Postsurgical Improvements in Pain, Function, Mental Health, and Self-image for Different Types of Adult Spinal Deformity. Spine. 2020
13. Passias P.G., Segreto F.A., Bortz C.A., Horn S.R., Pierce K.E., Naessig S., Brown A.E., Jackson-Fowl B., Ahmad W., Oh C., Lafage V., Lafage R., Smith J.S., Daniels A.H., Line B.G., Kim H.J., Uribe J.S., Eastlack R.K., Hamilton D.K., Klineberg E.O., Burton D.C., Hart R.A.A., Schwab F.J., Shaffrey C.I., Ames C.P., Bess S., International Spine Study Group. Probability of severe frailty development among operative and nonoperative adult spinal deformity patients: an actuarial survivorship analysis over a 3-year period. Spine Journal. 2020
14. Virk S., Passias P., Lafage R., Klineberg E., Mundis G., Protopsaltis T., Shaffrey C., Bess S., Burton D., Hart R., Kim H.J., Ames C., Schwab F., Smith J., Lafage V., International Spine Study Group. Intraoperative alignment goals for distinctive sagittal morphotypes of severe cervical deformity to achieve optimal improvements in health-related quality of life measures. Spine Journal. 2020
15. Jain A., Yeramaneni S., Kebaish K.M., Raad M., Gum J.L., Klineberg E.O., Hassanzadeh H., Kelly M.P., Passias P.G., Ames C.P., Smith J.S., Shaffrey C.I., Bess S., Lafage V., Glassman S., Carreon L.Y., Hostin R.A.. Cost-Utility Analysis of rhBMP-2 Use in Adult Spinal Deformity Surgery. Spine. 2020
16. Yang J., Lafage R., Gum J.L., Shaffrey C.I., Burton D., Kim H.J., Ames C.P., Mundis G., Hostin R., Bess S., Klineberg E.O., Smith J.S., Schwab F., Lafage V.. Group-based trajectory modeling: A novel approach to classifying discriminative functional status following adult spinal deformity surgery: Study of a 3-year follow-up group. Spine. 2020
17. Daniels A.H., Reid D., Durand W., Disilvestro K., Hamilton D.K., Passias P., Kim H.J., Protopsaltis T., LaFage V., Smith J.S., Shaffrey C., Gupta M., Klineberg E., Schwab F., Burton D., Bess S., Ames C., Hart R., International Spine Study Group. Sexual Dysfunction Secondary to Lumbar Stiffness in Adult Spinal Deformity Patients Before and After Long-Segment Spinal Fusion. World Neurosurgery. 2020
18. Daniels A.H., Reid D.B.C., Durand W.M., Line B., Passias P., Kim H.J., Protopsaltis T., LaFage V., Smith J.S., Shaffrey C., Gupta M., Klineberg E., Schwab F., Burton D., Bess S., Ames C., Hart R.A., International Spine Study Group. Assessment of Patient Outcomes and Proximal Junctional Failure Rate of Patients with Adult Spinal Deformity Undergoing Caudal Extension of Previous Spinal Fusion. World Neurosurgery. 2020
19. Segreto F.A., Passias P.G., Brown A.E., Horn S.R., Bortz C.A., Pierce K.E., Alas H., Lafage V., Lafage R., Smith J.S., Line B.G., Diebo B.G., Kelly M.P., Mundis G.M., Protopsaltis T.S., Soroceanu A., Kim H.J., Klineberg E.O., Burton D.C., Hart R.A., Schwab F.J., Bess S., Shaffrey C.I., Ames C.P.. The Influence of Surgical Intervention and Sagittal Alignment on Frailty in Adult Cervical Deformity. Operative Neurosurgery. 2020
20. Wang M.Y., Park P., Tran S., Anand N., Nunley P., Kanter A., Fessler R., Uribe J., Eastlack R., Shaffrey C.I., Bess S., Mundis G.M., Jr, Brusko G.D., Mummaneni P.V., The MIS-ISSG Group. Intermediate-term clinical and radiographic outcomes with less invasive adult spinal deformity surgery: patients with a minimum follow-up of 4 years. Acta Neurochirurgica. 2020
21. Wang M.Y., Uribe J., Mummaneni P.V., Tran S., Brusko G.D., Park P., Nunley P., Kanter A., Okonkwo D., Anand N., Chou D., Shaffrey C.I., Fu K.-M., Mundis G.M., Jr., Eastlack R., Minimally Invasive Surgery-International Spine Study Group. Minimally Invasive Spinal Deformity Surgery: Analysis of Patients Who Fail to Reach Minimal Clinically Important Difference. World Neurosurgery. 2020
22. Pierce K.E., Passias P.G., Alas H., Brown A.E., Bortz C.A., Lafage R., Lafage V., Ames C., Burton D.C., Hart R., Hamilton K., Kelly M., Hostin R., Bess S., Klineberg E., Line B., Shaffrey C., Mummaneni P., Smith J.S., Schwab F.A.. Does Patient Frailty Status Influence Recovery following Spinal Fusion for Adult Spinal Deformity?: An Analysis of Patients with 3-Year Follow-up. Spine. 2020
23. Goldschmidt E., Angriman F., Agarwal N., Trevisan M., Zhou J., Chen K., Gerszten P.C., Kanter A.S., Okonkwo D.O., Passias P., Scheer J., Protopsaltis T., Lafage V., Lafage R., Schwab F., Bess S., Ames C., Smith J.S., Shaffrey C.I., Miller E., Jain A., Neuman B., Sciubba D.M., Burton D., Hamilton D.K.. A New Piece of the Puzzle to Understand Cervical Sagittal Alignment: Utilizing a Novel Angle δto Describe the Relationship among T1 Vertebral Body Slope, Cervical Lordosis, and Cervical Sagittal Alignment. Clinical Neurosurgery. 2020
24. Ames C.P., Smith J.S., Gum J.L., Kelly M., Vila-Casademunt A., Burton D.C., Hostin R., Yeramaneni S., Lafage V., Schwab F.J., Shaffrey C.I., Bess S., Pellisé F., Serra-Burriel M.. Utilization of Predictive Modeling to Determine Episode of Care Costs and to Accurately Identify Catastrophic Cost Nonwarranty Outlier Patients in Adult Spinal Deformity Surgery: A Step Toward Bundled Payments and Risk Sharing. Spine. 2020
25. Line B.G., Bess S., Lafage R., Lafage V., Schwab F., Ames C., Kim H.J., Kelly M., Gupta M., Burton D., Hart R., Klineberg E., Kebaish K., Hostin R., Mundis G., Eastlack R., Shaffrey C., Smith J.S.. Effective Prevention of Proximal Junctional Failure in Adult Spinal Deformity Surgery Requires a Combination of Surgical Implant Prophylaxis and Avoidance of Sagittal Alignment Overcorrection. Spine. 2020
26. Protopsaltis T.S., Soroceanu A., Tishelman J.C., Buckland A.J., Mundis G.M., Jr., Smith J.S., Daniels A., Lenke L.G., Kim H.J., Klineberg E.O., Ames C.P., Hart R.A., Bess S., Shaffrey C.I., Schwab F.J., Lafage V.. Should Sagittal Spinal Alignment Targets for Adult Spinal Deformity Correction Depend on Pelvic Incidence and Age?. Spine. 2020
27. Plais N., Bao H., Lafage R., Gupta M., Smith J.S., Shaffrey C., Mundis G., Burton D., Ames C., Klineberg E., Bess S., Schwab F., Lafage V., International Spine Study Group. The clinical impact of global coronal malalignment is underestimated in adult patients with thoracolumbar scoliosis. Spine Deformity. 2020
28. Kim H.J., York P.J., Elysee J.C., Shaffrey C., Burton D.C., Ames C.P., Mundis G.M., Jr., Hostin R., Bess S., Klineberg E., Smith J.S., Passias P., Schwab F., Lafage R., the International Spine Study Group(ISSG). Cervical, Thoracic, and Spinopelvic Compensation After Proximal Junctional Kyphosis (PJK): Does Location of PJK Matter?. Global Spine Journal. 2020
29. Passias P.G., Bortz C.A., Lafage V., Lafage R., Smith J.S., Line B., Eastlack R., Gupta M.C., Hostin R.A., Jr., Horn S.R., Segreto F.A., Egers M., Sciubba D.M., Gum J.L., Kebaish K.M., Klineberg E.O., Burton D.C., Schwab F.J., Shaffrey C.I., Ames C.P., Bess S., International Spine Study Group (ISSG). Durability of satisfactory functional outcomes following surgical adult spinal deformity correction: A 3-year survivorship analysis. Operative Neurosurgery. 2020
30. Protopsaltis T.S., Ramchandran S., Tishelman J.C., Smith J.S., Neuman B.J., Mundis G.M.M., Lafage R., Klineberg E.O., Hamilton D.K., Lafage V., Gupta M.C., Hart R.A., Schwab F.J., Burton D.C., Bess S., Shaffrey C.I., Ames C.P., International Spine Study Group. The Importance of C2 Slope, a Singular Marker of Cervical Deformity, Correlates with Patient-reported Outcomes. Spine. 2020
31. Passias P.G., Horn S.R., Soroceanu A., Oh C., Ailon T., Neuman B.J., Lafage V., Lafage R., Smith J.S., Line B., Bortz C.A., Segreto F.A., Brown A., Alas H., Pierce K.E., Eastlack R.K., Sciubba D.M., Protopsaltis T.S., Klineberg E.O., Burton D.C., Hart R.A., Schwab F.J., Bess S., Shaffrey C.I., Ames C.P.. Development of a Novel Cervical Deformity Surgical Invasiveness Index. Spine. 2020
32. Decker S., Lafage R., Krettek C., Hart R., Ames C., Smith J.S., Burton D., Klineberg E., Bess S., Schwab F.J., Lafage V., International Spine Study Group. Is sacral extension a risk factor for early proximal junctional kyphosis in adult spinal deformity surgery?. Asian Spine Journal. 2020
33. Segreto F.A., Passias P.G., Lafage R., Lafage V., Smith J.S., Line B.G., Mundis G.M., Bortz C.A., Stekas N.D., Horn S.R., Diebo B.G., Brown A.E., Ihejirika Y., Nunley P.D., Daniels A.H., Gupta M.C., Gum J.L., Kojo Hamilton D., Klineberg E.O., Burton D.C., Hart R.A., Schwab F.J., Bess S., Shaffrey C.I., Ames C.P., International Spine Study Group. Incidence of acute, progressive, and delayed proximal junctional kyphosis over an 8-year period in adult spinal deformity patients. Operative Neurosurgery. 2020
34. Passias P.G., Horn S.R., Oh C., Lafage R., Lafage V., Smith J.S., Line B., Protopsaltis T.S., Yagi M., Bortz C.A., Segreto F.A., Alas H., Diebo B.G., Sciubba D.M., Kelly M.P., Daniels A.H., Klineberg E.O., Burton D.C., Hart R.A., Schwab F.J., Bess S., Shaffrey C.I., Ames C.P.. Predicting the Occurrence of Postoperative Distal Junctional Kyphosis in Cervical Deformity Patients. Neurosurgery. 2020
35. Beyer G., Khalifé M., Lafage R., Yang J., Elysee J., Frangella N., Steinmetz L., Ge D., Varlotta C., Stekas N., Manning J., Protopsaltis T., Passias P., Buckland A., Schwab F., Lafage V.. Pelvic Compensation in Sagittal Malalignment: How Much Retroversion Can the Pelvis Accommodate?. Spine. 2020
36. Kim H.J., Wang S.-J., Lafage R., Iyer S., Shaffrey C., Mundis G., Hostin R., Burton D., Ames C., Klineberg E., Gupta M., Smith J., Schwab F., Lafage V.. Recurrent Proximal Junctional Kyphosis: Incidence, Risk Factors, Revision Rates, and Outcomes at 2-Year Minimum Follow-up. Spine. 2020
37. Klineberg E.O., Passias P.G., Poorman G.W., Jalai C.M., Atanda A., Worley N., Horn S., Sciubba D.M., Hamilton D.K., Burton D.C., Gupta M.C., Smith J.S., Soroceanu A., Hart R.A., Neuman B., Ames C.P., Schwab F.J., Lafage V.. Classifying Complications: Assessing Adult Spinal Deformity 2-Year Surgical Outcomes. Global Spine Journal. 2020
38. Virk S., Elysee J., Gupta M., Klineberg E., Schwab F., Kim H.J., Burton D., Passias P., Protopsaltis T., Smith J., Ames C., Lafage R., Lafage V.. Defining an Algorithm of Treatment for Severe Cervical Deformity Using Surgeon Survey and Treatment Patterns. World Neurosurgery. 2020