Research

The International Spine Study Group works to consistently put forward high quality, meaningful research. The findings are shared via podium presentations, posters, and published manuscripts. Explore recent presentations and all publications from the ISSG here.

https://issgf.org/images/uploads/images/ISSG_Publications_2009-17.pdf

2018  Journal Publications (n=55)

  1. Ailon T, Hamilton DK, Klineberg E, Daniels AH, Lafage V, Bess S, et al. Radiographic Fusion Grade Does Not Impact Health-Related Quality of Life in the Absence of Instrumentation Failure for Patients Undergoing Posterior Instrumented Fusion for Adult Spinal Deformity. World Neurosurg 2018;117:e1–7. doi:10.1016/j.wneu.2018.04.127.
  2. Ailon T, Smith JS, Shaffrey CI, Kim HJ, Mundis G, Gupta M, et al. Outcomes of Operative Treatment for Adult Cervical Deformity: A Prospective Multicenter Assessment With 1-Year Follow-up. Neurosurgery 2018;83:1031–9. doi:10.1093/neuros/nyx574.
  3. Ailon T, Smith JS, Shaffrey CI, Soroceanu A, Lafage V, Schwab F, et al. Patients with Adult Spinal Deformity with Previous Fusions Have an Equal Chance of Reaching Substantial Clinical Benefit Thresholds in Health-Related Quality of Life Measures but Do Not Reach the Same Absolute Level of Improvement. World Neurosurg 2018;116:e354–61. doi:10.1016/j.wneu.2018.04.204.
  4. Bortz CA, Passias PG, Segreto FA, Horn SR, Lafage R, Smith JS, et al. Grading of Complications After Cervical Deformity-corrective Surgery: Are Existing Classification Systems Applicable? Clin Spine Surg 2018. doi:10.1097/BSD.0000000000000748.
  5. Buell TJ, Buchholz AL, Quinn JC, Bess S, Line BG, Ames CP, et al. A Pilot Study on Posterior Polyethylene Tethers to Prevent Proximal Junctional Kyphosis After Multilevel Spinal Instrumentation for Adult Spinal Deformity. Oper Neurosurg (Hagerstown, Md) 2018. doi:10.1093/ons/opy065.
  6. Challier V, Henry JK, Liu S, Ames C, Kebaish K, Obeid I, et al. Complication Rates and Maintenance of Correction After 3-Column Osteotomy in the Elderly: Report of 55 Patients With 2-Year Follow-up. Neurosurgery 2018;83:973–80. doi:10.1093/neuros/nyx580.
  7. Chou D, Mummaneni P, Anand N, Nunley P, La Marca F, Fu K-M, et al. Treatment of the Fractional Curve of Adult Scoliosis With Circumferential Minimally Invasive Surgery Versus Traditional, Open Surgery: An Analysis of Surgical Outcomes. Glob Spine J 2018;8:827–33. doi:10.1177/2192568218775069.
  8. Daniels AH, Bess S, Line B, Eltorai AEM, Reid DBC, Lafage V, et al. Peak Timing for Complications After Adult Spinal Deformity Surgery. World Neurosurg 2018;115:e509–15. doi:10.1016/j.wneu.2018.04.084.
  9. Daniels AH, DePasse JM, Durand W, Hamilton DK, Passias P, Kim HJ, et al. Rod Fracture After Apparently Solid Radiographic Fusion in Adult Spinal Deformity Patients. World Neurosurg 2018;117:e530–7. doi:10.1016/j.wneu.2018.06.071.
  10. Diebo BG, Lafage V, Varghese JJ, Gupta M, Kim HJ, Ames C, et al. After 9 Years of 3-Column Osteotomies, Are We Doing Better? Performance Curve Analysis of 573 Surgeries With 2-Year Follow-up. Neurosurgery 2018;83:69–75. doi:10.1093/neuros/nyx338.
  11. Eastlack RK, Ledesma JB, Tran S, Khalsa A, Park P, Mummaneni P V, et al. Home Versus Rehabilitation: Factors that Influence Disposition After Minimally Invasive Surgery in Adult Spinal Deformity Surgery. World Neurosurg 2018;118:e610–5. doi:10.1016/j.wneu.2018.06.249.
  12. Goldschmidt E, Angriman F, Ferreyro B, Agarwal N, Zhou J, Chen K, et al. Design and Testing of 2 Novel Scores That Predict Global Sagittal Alignment Utilizing Cervical or Lumbar Plain Radiographs. Neurosurgery 2018;82:163–71. doi:10.1093/neuros/nyx178.
  13. Hosogane N, Ames C, Matsumoto M, Yagi M, Matsuyama Y, Taneichi H, et al. Ethnic Variations in Radiographic Parameters and SRS-22 Scores in Adult Spinal Deformity: A Comparison Between North American and Japanese Patients Above 50 Years of Age With Minimum 2-Year Follow-up. Clin Spine Surg 2018;31:216–21. doi:10.1097/BSD.0000000000000610.
  14. International Spine Study Group. Cervical mismatch: the normative value of T1 slope minus cervical lordosis and its ability to predict ideal cervical lordosis. J Neurosurg Spine 2018:1–7. doi:10.3171/2018.5.SPINE171232.
  15. Iyer S, Klineberg EO, Zebala LP, Kelly MP, Hart RA, Gupta MC, et al. Dural Tears in Adult Deformity Surgery: Incidence, Risk Factors, and Outcomes. Glob Spine J 2018;8:25–31. doi:10.1177/2192568217717973.
  16. Kelly MP, Kim HJ, Ames CP, Burton DC, Carreon LY, Polly DW, et al. Minimum Detectable Measurement Difference for Health-Related Quality of Life Measures Varies With Age and Disability in Adult Spinal Deformity: Implications for Calculating Minimal Clinically Important Difference. Spine (Phila Pa 1976) 2018;43:E790–5. doi:10.1097/BRS.0000000000002519.
  17. Khalsa AS, Mundis GM, Yagi M, Fessler RG, Bess S, Hosogane N, et al. Variability in Assessing Spinopelvic Parameters With Lumbosacral Transitional Vertebrae: Inter- and Intraobserver Reliability Among Spine Surgeons. Spine (Phila Pa 1976) 2018;43:813–6. doi:10.1097/BRS.0000000000002433.
  18. Kim HJ, Iyer S, Diebo BG, Kelly MP, Sciubba D, Schwab F, et al. Clinically Significant Thromboembolic Disease in Adult Spinal Deformity Surgery: Incidence and Risk Factors in 737 Patients. Glob Spine J 2018;8:224–30. doi:10.1177/2192568217724781.
  19. Lafage R, Obeid I, Liabaud B, Bess S, Burton D, Smith JS, et al. Location of correction within the lumbar spine impacts acute adjacent-segment kyphosis. J Neurosurg Spine 2018:1–9. doi:10.3171/2018.6.SPINE161468.
  20. Miller EK, Ailon T, Neuman BJ, Klineberg EO, Mundis GM, Sciubba DM, et al. Assessment of a Novel Adult Cervical Deformity Frailty Index as a Component of Preoperative Risk Stratification. World Neurosurg 2018;109:e800–6. doi:10.1016/j.wneu.2017.10.092.
  21. Miller EK, Lenke LG, Neuman BJ, Sciubba DM, Kebaish KM, Smith JS, et al. External Validation of the Adult Spinal Deformity (ASD) Frailty Index (ASD-FI) in the Scoli-RISK-1 Patient Database. Spine (Phila Pa 1976) 2018;43:1426–31. doi:10.1097/BRS.0000000000002717.
  22. Miller EK, Vila-Casademunt A, Neuman BJ, Sciubba DM, Kebaish KM, Smith JS, et al. External validation of the adult spinal deformity (ASD) frailty index (ASD-FI). Eur Spine J 2018;27:2331–8. doi:10.1007/s00586-018-5575-3.
  23. Neuman BJ, Ailon T, Scheer JK, Klineberg E, Sciubba DM, Jain A, et al. Development and Validation of a Novel Adult Spinal Deformity Surgical Invasiveness Score: Analysis of 464 Patients. Neurosurgery 2018;82:847–53. doi:10.1093/neuros/nyx303.
  24. Passias PG, Bortz CA, Segreto FA, Horn SR, Lafage R, Lafage V, et al. Development of a Modified Cervical Deformity Frailty Index: A Streamlined Clinical Tool for Preoperative Risk Stratification. Spine (Phila Pa 1976) 2018. doi:10.1097/BRS.0000000000002778.
  25. Passias PG, Bortz C, Horn S, Segreto F, Poorman G, Jalai C, et al. Drivers of Cervical Deformity Have a Strong Influence on Achieving Optimal Radiographic and Clinical Outcomes at 1 Year After Cervical Deformity Surgery. World Neurosurg 2018;112:e61–8. doi:10.1016/j.wneu.2017.12.024.
  26. Passias PG, Horn SR, Jalai CM, Ramchandran S, Poorman GW, Kim HJ, et al. Cervical Alignment Changes in Patients Developing Proximal Junctional Kyphosis Following Surgical Correction of Adult Spinal Deformity. Neurosurgery 2018;83:675–82. doi:10.1093/neuros/nyx479.
  27. Passias PG, Horn SR, Oh C, Ramchandran S, Burton DC, Lafage V, et al. Evaluating cervical deformity corrective surgery outcomes at 1-year using current patient-derived and functional measures: are they adequate? J Spine Surg (Hong Kong) 2018;4:295–303. doi:10.21037/jss.2018.05.29.
  28. Passias PG, Horn SR, Poorman GW, Daniels AH, Hamilton DK, Kim HJ, et al. Clinical and radiographic presentation and treatment of patients with cervical deformity secondary to thoracolumbar proximal junctional kyphosis are distinct despite achieving similar outcomes: Analysis of 123 prospective CD cases. J Clin Neurosci 2018;56:121–6. doi:10.1016/j.jocn.2018.06.040.
  29. Passias PG, Jalai CM, Lafage V, Lafage R, Protopsaltis T, Ramchandran S, et al. Primary Drivers of Adult Cervical Deformity: Prevalence, Variations in Presentation, and Effect of Surgical Treatment Strategies on Early Postoperative Alignment. Neurosurgery 2018;83:651–9. doi:10.1093/neuros/nyx438.
  30. Passias PG, Jalai CM, Lafage V, Poorman GW, Vira S, Horn SR, et al. Recovery Kinetics of Radiographic and Implant-Related Revision Patients Following Adult Spinal Deformity Surgery. Neurosurgery 2018;83:700–8. doi:10.1093/neuros/nyx490.
  31. Passias PG, Jalai CM, Line BG, Poorman GW, Scheer JK, Smith JS, et al. Patient profiling can identify patients with adult spinal deformity (ASD) at risk for conversion from nonoperative to surgical treatment: initial steps to reduce ineffective ASD management. Spine J 2018;18:234–44. doi:10.1016/j.spinee.2017.06.044.
  32. Passias PG, Jalai CM, Smith JS, Lafage V, Diebo BG, Protopsaltis T, et al. Characterizing Adult Cervical Deformity and Disability Based on Existing Cervical and Adult Deformity Classification Schemes at Presentation and Following Correction. Neurosurgery 2018;82:192–201. doi:10.1093/neuros/nyx175.
  33. Passias PG, Vasquez-Montes D, Poorman GW, Protopsaltis T, Horn SR, Bortz CA, et al. Predictive model for distal junctional kyphosis after cervical deformity surgery. Spine J 2018;18:2187–94. doi:10.1016/j.spinee.2018.04.017.
  34. Passias PG, Horn SR, Bortz CA, Ramachandran S, Burton DC, Protopsaltis T, et al. The Relationship Between Improvements in Myelopathy and Sagittal Realignment in Cervical Deformity Surgery Outcomes. Spine (Phila Pa 1976) 2018;43:1117–24. doi:10.1097/BRS.0000000000002610.
  35. Poorman GW, Passias PG, Qureshi R, Hassanzadeh H, Horn S, Bortz C, et al. Cost-utility analysis of cervical deformity surgeries using 1-year outcome. Spine J 2018;18:1552–7. doi:10.1016/j.spinee.2018.01.016.
  36. Protopsaltis TS, Diebo BG, Lafage R, Henry JK, Smith JS, Scheer JK, et al. Identifying Thoracic Compensation and Predicting Reciprocal Thoracic Kyphosis and Proximal Junctional Kyphosis in Adult Spinal Deformity Surgery. Spine (Phila Pa 1976) 2018;43:1479–86. doi:10.1097/BRS.0000000000002843.
  37. Protopsaltis TS, Lafage R, Smith JS, Passias PG, Shaffrey CI, Kim HJ, et al. The Lumbar Pelvic Angle, the Lumbar Component of the T1 Pelvic Angle, Correlates With HRQOL, PI-LL Mismatch, and it Predicts Global Alignment. Spine (Phila Pa 1976) 2018;43:681–7. doi:10.1097/BRS.0000000000002346.
  38. Protopsaltis TS, Ramchandran S, Hamilton DK, Sciubba D, Passias PG, Lafage V, et al. Analysis of Successful Versus Failed Radiographic Outcomes After Cervical Deformity Surgery. Spine (Phila Pa 1976) 2018;43:E773–81. doi:10.1097/BRS.0000000000002524.
  39. Protopsaltis T, Terran J, Soroceanu A, Moses MJ, Bronsard N, Smith J, et al. T1 Slope Minus Cervical Lordosis (TS-CL), the Cervical Answer to PI-LL, Defines Cervical Sagittal Deformity in Patients Undergoing Thoracolumbar Osteotomy. Int J Spine Surg 2018;12:362–70. doi:10.14444/5042.
  40. Raad M, Neuman BJ, Jain A, Hassanzadeh H, Passias PG, Klineberg E, et al. The use of patient-reported preoperative activity levels as a stratification tool for short-term and long-term outcomes in patients with adult spinal deformity. J Neurosurg Spine 2018;29:68–74. doi:10.3171/2017.10.SPINE17830.
  41. Ramchandran S, Protopsaltis TS, Sciubba D, Scheer JK, Jalai CM, Daniels A, et al. Prospective multi-centric evaluation of upper cervical and infra-cervical sagittal compensatory alignment in patients with adult cervical deformity. Eur Spine J 2018;27:416–25. doi:10.1007/s00586-017-5395-x.
  42. Reid DBC, Daniels AH, Ailon T, Miller E, Sciubba DM, Smith JS, et al. Frailty and Health-Related Quality of Life Improvement Following Adult Spinal Deformity Surgery. World Neurosurg 2018;112:e548–54. doi:10.1016/j.wneu.2018.01.079.
  43. Safaee MM, Scheer JK, Ailon T, Smith JS, Hart RA, Burton DC, et al. Predictive Modeling of Length of Hospital Stay Following Adult Spinal Deformity Correction: Analysis of 653 Patients with an Accuracy of 75% within 2 Days. World Neurosurg 2018;115:e422–7. doi:10.1016/j.wneu.2018.04.064.
  44. Scheer JK, Lafage R, Schwab FJ, Liabaud B, Smith JS, Mundis GM, et al. Under Correction of Sagittal Deformities Based on Age-adjusted Alignment Thresholds Leads to Worse Health-related Quality of Life Whereas Over Correction Provides No Additional Benefit. Spine (Phila Pa 1976) 2018;43:388–93. doi:10.1097/BRS.0000000000002435.
  45. Scheer JK, Oh T, Smith JS, Shaffrey CI, Daniels AH, Sciubba DM, et al. Development of a validated computer-based preoperative predictive model for pseudarthrosis with 91% accuracy in 336 adult spinal deformity patients. Neurosurg Focus 2018;45:E11. doi:10.3171/2018.8.FOCUS18246.
  46. Scheer JK, Osorio JA, Smith JS, Schwab F, Hart RA, Hostin R, et al. Development of a Preoperative Predictive Model for Reaching the Oswestry Disability Index Minimal Clinically Important Difference for Adult Spinal Deformity Patients. Spine Deform 2018;6:593–9. doi:10.1016/j.jspd.2018.02.010.
  47. Segreto FA, Lafage V, Lafage R, Smith JS, Line BG, Eastlack RK, et al. Recovery Kinetics: Comparison of Patients undergoing Primary or Revision Procedures for Adult Cervical Deformity Using a Novel Area Under the Curve Methodology. Neurosurgery 2018. doi:10.1093/neuros/nyy435.
  48. Smith JS, Shaffrey CI, Kim HJ, Passias P, Protopsaltis T, Lafage R, et al. Prospective Multicenter Assessment of All-Cause Mortality Following Surgery for Adult Cervical Deformity. Neurosurgery 2018;83:1277–85. doi:10.1093/neuros/nyx605.
  49. Uribe JS, Januszewski J, Wang M, Anand N, Okonkwo DO, Mummaneni P V, et al. Patients with High Pelvic Tilt Achieve the Same Clinical Success as Those with Low Pelvic Tilt After Minimally Invasive Adult Deformity Surgery. Neurosurgery 2018;83:270–6. doi:10.1093/neuros/nyx383.
  50. Verma R, Lafage R, Scheer J, Smith J, Passias P, Hostin R, et al. Improvement in Back and Leg Pain and Disability Following Adult Spinal Deformity Surgery: Study of 324 Patients With 2-year Follow-up and the Impact of Surgery on Patient-reported Outcomes. Spine (Phila Pa 1976) 2018. doi:10.1097/BRS.0000000000002815.
  51. Yagi M, Ames CP, Keefe M, Hosogane N, Smith JS, Shaffrey CI, et al. A cost-effectiveness comparisons of adult spinal deformity surgery in the United States and Japan. Eur Spine J 2018;27:678–84. doi:10.1007/s00586-017-5274-5.
  52. Yang J, Khalifé M, Lafage R, Kim HJ, Smith J, Shaffrey CI, et al. What Factors Predict the Risk of Proximal Junctional Failure in the Long Term, Demographic, Surgical or Radiographic? Results from a Time-Dependent ROC Curve. Spine (Phila Pa 1976) 2018. doi:10.1097/BRS.0000000000002955.
  53. Yeramaneni S, Ames CP, Bess S, Burton D, Smith JS, Glassman S, et al. Center variation in episode-of-care costs for adult spinal deformity surgery: results from a prospective, multicenter database. Spine J 2018;18:1829–36. doi:10.1016/j.spinee.2018.03.012.
  54. Passias PG, Oh C, Horn SR, Kim HJ, Hamilton DK, Sciubba DM, et al. Predicting the occurrence of complications following corrective cervical deformity surgery: Analysis of a prospective multicenter database using predictive analytics. J Clin Neurosci 2019;59:155–61. doi:10.1016/j.jocn.2018.10.111.
  55. Yang J, Lafage V, Lafage R, Smith J, Klineberg EO, Shaffrey CI, et al. Determinants of Patient Satisfaction 2 Years After Spinal Deformity Surgery: A Latent Class Analysis. Spine (Phila Pa 1976) 2019;44:E45–52. doi:10.1097/BRS.0000000000002753.

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