Research

The International Spine Study Group works to consistently put forward high quality, meaningful research. The findings are shared via podium presentations, posters, and published manuscripts. Explore recent presentations and all publications from the ISSG here.

 

ISSG Journal Articles 1–116

1.           Bess S; Boachie-Adjei O; Burton D; Cunningham M; Shaffrey C; Shelokov A; Hostin R; Schwab F; Wood K & Akbarnia B. Pain and disability determine treatment modality for older patients with adult scoliosis, while deformity guides treatment for younger patients. Spine (Phila. Pa. 1976). 34, 2186–90 (2009).

2.           Klineberg E; Schwab F; Ames CP; Hostin R; Bess S; Smith JS; Gupta MC; Boachie O; Hart R a; Akbarnia B a; Burton DC & Lafage V. Acute reciprocal changes distant from the site of spinal osteotomies affect global postoperative alignment. Adv. Orthop. 2011, 415946 (2011).

3.           Lafage V; Schwab F; Vira S; Hart R; Burton D; Smith JS; Boachie-Adjei O; Shelokov A; Hostin R; Shaffrey CI; Gupta M; Akbarnia B a; Bess S & Farcy J-P. Does vertebral level of pedicle subtraction osteotomy correlate with degree of spinopelvic parameter correction? J. Neurosurg. Spine 14, 184–91 (2011).

4.           Ames CP; Smith JS; Scheer JK; Bess S; Bederman SS; Deviren V; Lafage V; Schwab F & Shaffrey CI. Impact of spinopelvic alignment on decision making in deformity surgery in adults: A review. J. Neurosurg. Spine 16, 547–64 (2012).

5.           Hostin R; McCarthy I; O’Brien M; Bess S; Line B; Boachie-Adjei O; Burton D; Gupta M; Ames C; Deviren V; Kebaish K; Shaffrey C; Wood K & Hart R. Incidence, Mode, and Location of Acute Proximal Junctional Failures Following Surgical Treatment for Adult Spinal Deformity. Spine (Phila. Pa. 1976). 38, 1008–1015 (2012).

6.           Lafage V; Ames C; Schwab F; Klineberg E; Akbarnia B; Smith J; Boachie-Adjei O; Burton D; Hart R; Hostin R; Shaffrey C; Wood K & Bess S. Changes in thoracic kyphosis negatively impact sagittal alignment after lumbar pedicle subtraction osteotomy: a comprehensive radiographic analysis. Spine (Phila. Pa. 1976). 37, E180–7 (2012).

7.           Lafage V; Bharucha NJ; Schwab F; Hart R a; Burton D; Boachie-Adjei O; Smith JS; Hostin R; Shaffrey C; Gupta M; Akbarnia B a & Bess S. Multicenter validation of a formula predicting postoperative spinopelvic alignment. J. Neurosurg. Spine 16, 15–21 (2012).

8.           Lafage V; Smith JS; Bess S; Schwab FJ; Ames CP; Klineberg E; Arlet V; Hostin R; Burton DC & Shaffrey CI. Sagittal spino-pelvic alignment failures following three column thoracic osteotomy for adult spinal deformity. Eur. Spine J. 21, 698–704 (2012).

9.           Schwab F; Hawkinson N; Lafage V; Smith JS; Hart R; Mundis G; Burton DC; Line B; Akbarnia B a; Boachie-Adjei O; Hostin R; Shaffrey CI; Arlet V; Wood K; Gupta M; Bess S & Mummaneni P V. Risk factors for major peri-operative complications in adult spinal deformity surgery: a multi-center review of 953 consecutive patients. Eur. Spine J. 21, 2603–10 (2012).

10.        Schwab F; Patel A; Shaffrey CI; Smith JS; Farcy J-P; Boachie-Adjei O; Hostin R; Hart R a; Akbarnia B a; Burton DC; Bess S & Lafage V. Sagittal realignment failures following pedicle subtraction osteotomy surgery: are we doing enough? J. Neurosurg. Spine 16, 539–46 (2012).

11.        Smith JS; Bess S; Shaffrey CI; Burton DC; Hart R a; Hostin R & Klineberg E. Dynamic changes of the pelvis and spine are key to predicting postoperative sagittal alignment after pedicle subtraction osteotomy: a critical analysis of preoperative planning techniques. Spine (Phila. Pa. 1976). 37, 845–53 (2012).

12.        Smith JS; Shaffrey CI; Ames CP; Demakakos J; Fu K-MG; Keshavarzi S; Li CMY; Deviren V; Schwab F; Lafage V & Bess S. Assessment of symptomatic rod fracture after posterior instrumented fusion for adult spinal deformity. Neurosurgery 71, 862–7 (2012).

13.        Smith JS; Shaffrey CI; Lafage V; Blondel B; Schwab F; Hostin R; Hart R; O’Shaughnessy B; Bess S; Hu SS; Deviren V & Ames CP. Spontaneous improvement of cervical alignment after correction of global sagittal balance following pedicle subtraction osteotomy. J. Neurosurg. Spine 17, 300–7 (2012).

14.        Tang J a; Scheer JK; Smith JS; Deviren V; Bess S; Hart R a; Lafage V; Shaffrey CI; Schwab F & Ames CP. The impact of standing regional cervical sagittal alignment on outcomes in posterior cervical fusion surgery. Neurosurgery 71, 662–9; discussion 669 (2012).

15.        Akbar M; Terran J; Ames CP; Lafage V & Schwab F. Use of Surgimap Spine in sagittal plane analysis, osteotomy planning, and correction calculation. Neurosurg. Clin. N. Am. 24, 163–72 (2013).

16.        Ames CP; Smith JS; Scheer JK; Shaffrey CI; Lafage V; Deviren V; Moal B; Protopsaltis T; Mummaneni P V; Mundis GM; Hostin R; Klineberg E; Burton DC; Hart R; Bess S & Schwab F. A standardized nomenclature for cervical spine soft-tissue release and osteotomy for deformity correction. J. Neurosurg. Spine (2013). doi:10.3171/2013.5.SPINE121067

17.        Bess S; Schwab F; Lafage V; Shaffrey CI & Ames CP. Classifications for adult spinal deformity and use of the Scoliosis Research Society-Schwab Adult Spinal Deformity Classification. Neurosurg. Clin. N. Am. 24, 185–93 (2013).

18.        Blondel B; Schwab F; Bess S; Ames CP; Mummaneni P V; Hart R; Smith JS; Shaffrey CI; Burton D; Boachie-Adjei O & Lafage V. Posterior global malalignment after osteotomy for sagittal plane deformity: it happens and here is why. Spine (Phila. Pa. 1976). 38, E394–401 (2013).

19.        Fu K-MG; Smith JS; Burton DC; Shaffrey CI; Boachie-Adjei O; Carlson B; Schwab FJ; Lafage V; Hostin R; Bess S; Akbarnia B a; Mundis G; Klineberg E & Gupta M. Outcomes and complications of extension of previous long fusion to the sacro-pelvis: is an anterior approach necessary? World Neurosurg. 79, 177–81 (2013).

20.        Fu K-MG; Smith JS; Shaffrey CI; Ames CP & Bess S. Coronal realignment and reduction techniques and complication avoidance. Neurosurg. Clin. N. Am. 24, 195–202 (2013).

21.        Gupta MC; Kebaish K; Blondel B & Klineberg E. Spinal osteotomies for rigid deformities. Neurosurg. Clin. N. Am. 24, 203–11 (2013).

22.        Hart R a; Cabalo A; Bess S; Akbarnia B a; Boachie-Adjei O; Burton D; Cunningham ME; Gupta M; Hostin R; Kebaish K; Klineberg E; Mundis G; Shaffrey C; Smith JS & Wood K. Comparison of patient and surgeon perceptions of adverse events after adult spinal deformity surgery. Spine (Phila. Pa. 1976). 38, 732–6 (2013).

23.        Hart R a; McCarthy I; Ames CP; Shaffrey CI; Hamilton DK & Hostin R. Proximal junctional kyphosis and proximal junctional failure. Neurosurg. Clin. N. Am. 24, 213–8 (2013).

24.        Hart R; McCarthy I; Oʼbrien M; Bess S; Line B; Adjei OB; Burton D; Gupta M; Ames C; Deviren V; Khaled Kebaish; Shaffrey C; Wood K & Hostin R. Identification of Decision Criteria for Revision Surgery among Patients with Proximal Junctional Failure following Surgical Treatment for Spinal Deformity. Spine (Phila. Pa. 1976). 38, 1223–1227 (2013).

25.        Hostin R; O’Brien M; McCarthy I; Bess S; Gupta M & Klineberg E. Retrospective Study of Anterior Interbody Fusion Rates and Patient Outcomes of Using Mineralized Collagen and Bone Marrow Aspirate in Multilevel Adult Spinal Deformity Surgery. J. Spinal Disord. Tech. (2013). doi:10.1097/BSD.0b013e318292468f

26.        Kasliwal MK; Smith JS; Kanter A; Chen C-J; Mummaneni P V; Hart R a & Shaffrey CI. Management of high-grade spondylolisthesis. Neurosurg. Clin. N. Am. 24, 275–91 (2013).

27.        Klineberg E; Schwab F; Smith JS; Gupta MC; Lafage V & Bess S. Sagittal spinal pelvic alignment. Neurosurg. Clin. N. Am. 24, 157–62 (2013).

28.        McCarthy IM; Hostin R a; O’Brien MF; Fleming NS; Ogola G; Kudyakov R; Richter KM; Saigal R; Berven SH & Ames CP. Analysis of the direct cost of surgery for four diagnostic categories of adult spinal deformity. Spine J. 13, 1843–8 (2013).

29.        McCarthy I; Hostin R; O’Brien M; Fleming N; Ogola G; Kudyakov R; Richter K; Saigal R; Berven S; Deviren V & Ames C. Cost-Effectiveness of Surgical Treatment for Adult Spinal Deformity: A Comparison of Dollars per Quality of Life Improvement Across Health Domains. Spine Deform. 1, 293–298 (2013).

30.        McCarthy I; Hostin R; O’Brien M; Saigal R & Ames CP. Health economic analysis of adult deformity surgery. Neurosurg. Clin. N. Am. 24, 293–304 (2013).

31.        Mummaneni P V; Tu T-H; Ziewacz JE; Akinbo OC; Deviren V & Mundis GM. The role of minimally invasive techniques in the treatment of adult spinal deformity. Neurosurg. Clin. N. Am. 24, 231–48 (2013).

32.        Scheer JK; Ames CP & Deviren V. Assessment and treatment of cervical deformity. Neurosurg. Clin. N. Am. 24, 249–74 (2013).

33.        Scheer JK; Tang J a; Smith JS; Acosta FL; Protopsaltis TS; Blondel B; Bess S; Shaffrey CI; Deviren V; Lafage V; Schwab F & Ames CP. Cervical spine alignment, sagittal deformity, and clinical implications. J. Neurosurg. Spine 19, 141–59 (2013).

34.        Scheer JK; Tang J a; Smith JS; Klineberg E; Hart R a; Mundis GM; Burton DC; Hostin R; O’Brien MF; Bess S; Kebaish KM; Deviren V; Lafage V; Schwab F; Shaffrey CI & Ames CP. Reoperation rates and impact on outcome in a large, prospective, multicenter, adult spinal deformity database: clinical article. J. Neurosurg. Spine 19, 464–70 (2013).

35.        Schwab F; Blondel B; Bess S; Hostin R; Shaffrey CI; Smith JS; Boachie-Adjei O; Burton DC; Akbarnia B a; Mundis GM; Ames CP; Kebaish K; Hart R a; Farcy J-P & Lafage V. Radiographical spinopelvic parameters and disability in the setting of adult spinal deformity: a prospective multicenter analysis. Spine (Phila. Pa. 1976). 38, E803–12 (2013).

36.        Smith JS; Klineberg E; Schwab F; Shaffrey CI; Moal B; Ames CP; Hostin R; Fu K-MG; Burton D; Akbarnia B; Gupta M; Hart R; Bess S & Lafage V. Change in Classification Grade by the SRS-Schwab Adult Spinal Deformity Classification Predicts Impact on Health-Related Quality of Life Measures: Prospective Analysis of Operative and Non-operative Treatment. Spine (Phila. Pa. 1976). (2013). doi:10.1097/BRS.0b013e31829ec563

37.        Smith JS; Shaffrey CI; Fu K-MG; Scheer JK; Bess S; Lafage V; Schwab F & Ames CP. Clinical and radiographic evaluation of the adult spinal deformity patient. Neurosurg. Clin. N. Am. 24, 143–56 (2013).

38.        Terran J; Schwab F; Shaffrey CI; Smith JS; Devos P; Ames CP; Fu KMG; Burton D; Hostin R; Klineberg E; Gupta M; Deviren V; Mundis G; Hart R; Bess S & Lafage V. The SRS-schwab adult spinal deformity classification: Assessment and clinical correlations based on a prospective operative and nonoperative cohort. Neurosurgery 73, 559–568 (2013).

39.        Bess S; Line BG; Lafage V; Schwab F; Shaffrey CI; Hart R a; Boachie-Adjei O; Akbarnia B a; Ames CP; Burton DC; Deverin V; Fu K-MG; Gupta M; Hostin R; Kebaish K; Klineberg E; Mundis G; O’Brien M; et al. Does recombinant human bone morphogenetic protein-2 use in adult spinal deformity increase complications and are complications associated with location of rhBMP-2 use? A prospective, multicenter study of 279 consecutive patients. Spine (Phila. Pa. 1976). 39, 233–42 (2014).

40.        Bianco K; Norton R; Schwab F; Smith JS; Klineberg E; Obeid I; Mundis G; Shaffrey CI; Kebaish K; Hostin R; Hart R; Gupta MC; Burton D; Ames C; Boachie-Adjei O; Protopsaltis TS & Lafage V. Complications and intercenter variability of three-column osteotomies for spinal deformity surgery: a retrospective review of 423 patients. Neurosurg. Focus 36, E18 (2014).

41.        Clark AJ; Garcia RM; Keefe MK; Koski TR; Rosner MK; Smith JS; Cheng JS; Shaffrey CI; McCormick PC & Ames CP. Results of the AANS membership survey of adult spinal deformity knowledge: impact of training, practice experience, and assessment of potential areas for improved education. J. Neurosurg. Spine 21, 640–647 (2014).

42.        Fu KMG; Smith JS; Burton DC; Kebaish KM; Shaffrey CI; Schwab F; Lafage V; Arlet V; Hostin R; Boachie O; Akbarnia B & Bess S. Revision Extension to the Pelvis versus Primary Spinopelvic Instrumentation in Adult Deformity: Comparison of Clinical Outcomes and Complications. World Neurosurg. (2014). doi:10.1016/j.wneu.2013.02.059

43.        Fu K-MG; Bess S; Shaffrey CI; Smith JS; Lafage V; Schwab F; Burton DC; Akbarnia B a; Ames CP; Boachie-Adjei O; Deverin V; Hart R a; Hostin R; Klineberg E; Gupta M; Kebaish K; Mundis G & Mummaneni P V. Adult Spinal Deformity Patients Treated Operatively Report Greater Baseline Pain and Disability than Patients Treated Nonoperatively: However, Deformities Differ Between Age Groups. Spine (Phila. Pa. 1976). (2014). doi:10.1097/BRS.0000000000000414

44.        Haque RM; Mundis GM; Ahmed Y; El Ahmadieh TY; Wang MY; Mummaneni P V; Uribe JS; Okonkwo DO; Eastlack RK; Anand N; Kanter AS; La Marca F; Akbarnia B a; Park P; Lafage V; Terran JS; Shaffrey CI; Klineberg E; et al. Comparison of radiographic results after minimally invasive, hybrid, and open surgery for adult spinal deformity: a multicenter study of 184 patients. Neurosurg. Focus 36, E13 (2014).

45.        Kim HJ; Boachie-Adjei O; Shaffrey CI; Schwab F; Lafage V; Bess S; Gupta MC; Smith JS; Deviren V; Akbarnia B; Mundis GM; O’Brien M; Hostin R; Ames C & OʼBrien M. Upper Thoracic versus Lower Thoracic Upper Instrumented Vertebrae Endpoints have Similar Outcomes and Complications in Adult Scoliosis. Spine (Phila. Pa. 1976). 39, E795–9 (2014).

46.        Lafage V; Blondel B; Smith JS; Boachie-Adjei O; Hostin R a.; Burton D; Mundis G; Klineberg E; Ames C; Akbarnia B; Bess S & Schwab F. Preoperative Planning for Pedicle Subtraction Osteotomy: Does Pelvic Tilt Matter? Spine Deform. 2, 358–366 (2014).

47.        Liu S; Schwab F; Smith JS; Klineberg E; Ames CP; Mundis G; Hostin R; Kebaish K; Deviren V; Gupta M; Boachie-Adjei O; Hart R a; Bess S & Lafage V. Likelihood of reaching minimal clinically important difference in adult spinal deformity: a comparison of operative and nonoperative treatment. Ochsner J. 14, 67–77 (2014).

48.        Maier S; Smith JS; Schwab F; Obeid I; Mundis G; Klineberg E; Hostin R; Hart R; Burton D; Boachie-Adjei O; Gupta M; Ames C; Protopsaltis T; Lafage V & International Spine Study Group. Revision Surgery After Three-Column Osteotomy in 335 Adult Spinal Deformity Patients: Inter-Center Variability and Risk Factors. Spine (Phila. Pa. 1976). 39, 881–885 (2014).

49.        McCarthy IM; Hostin RA; Ames CP; Kim HJ; Smith JP; Boachie-Adjei O; Schwab FJ; Klineberg EO; Shaffrey CI; Gupta MC & Polly DW. Total hospital costs of surgical treatment for adult spinal deformity: an extended follow-up study. Spine J. 1–7 (2014). doi:10.1016/j.spinee.2014.01.032

50.        McCarthy I; O’Brien M; Ames C; Robinson C; Errico T; Polly DW & Hostin R. Incremental cost-effectiveness of adult spinal deformity surgery: observed quality-adjusted life years with surgery compared with predicted quality-adjusted life years without surgery. Neurosurg. Focus 36, E3 (2014).

51.        Moal B; Schwab F; Ames CP; Smith JS; Ryan D; Mummaneni P V; Mundis GM; Terran JS; Klineberg E; Hart RA; Boachie-adjei O; Shaffrey CI; Skalli W; Lafage V & International Spine Study Group. Radiographic Outcomes of Adult Spinal Deformity Correction: A Critical Analysis of Variability and Failures Across Deformity Patterns. Spine Deform. 2, 19–255 (2014).

52.        Mummaneni P V; Shaffrey CI; Lenke LG; Park P; Wang MY; La Marca F; Smith JS; Mundis GM; Okonkwo DO; Moal B; Fessler RG; Anand N; Uribe JS; Kanter AS; Akbarnia B & Fu K-MG. The minimally invasive spinal deformity surgery algorithm: a reproducible rational framework for decision making in minimally invasive spinal deformity surgery. Neurosurg. Focus 36, E6 (2014).

53.        Protopsaltis T; Schwab F; Bronsard N; Smith JS; Klineberg E; Mundis G; Ryan DJ; Hostin R; Hart R; Burton D; Ames C; Shaffrey C; Bess S; Errico T & Lafage V. The T1 Pelvic Angle, a Novel Radiographic Measure of Global Sagittal Deformity, Accounts for Both Spinal Inclination and Pelvic Tilt and Correlates with Health-Related Quality of Life. J. Bone Jt. Surg. 96, 1631–1640 (2014).

54.        Ryan DJ; Protopsaltis TS; Ames CP; Hostin R; Klineberg E; Mundis GM; Obeid I; Kebaish K; Smith JS; Boachie-Adjei O; Burton DC; Hart R a.; Gupta M; Schwab FJ & Lafage V. T1 Pelvic Angle (TPA) Effectively Evaluates Sagittal Deformity and Assesses Radiographical Surgical Outcomes Longitudinally. Spine (Phila. Pa. 1976). 39, 1203–1210 (2014).

55.        Scheer JK; Lafage V; Smith JS; Deviren V; Hostin R; McCarthy IM; Mundis GM; Burton DC; Klineberg E; Gupta M; Kebaish K; Shaffrey CI; Bess S; Schwab F & Ames CP. Maintenance of radiographic correction at 2 years following lumbar pedicle subtraction osteotomy is superior with upper thoracic compared with thoracolumbar junction upper instrumented vertebra. Eur. Spine J. (2014). doi:10.1007/s00586-014-3391-y

56.        Scheer JK; Lafage V; Smith JS; Deviren V; Hostin R; McCarthy IM; Mundis GM; Burton DC; Klineberg E; Gupta MC; Kebaish KM; Shaffrey CI; Bess S; Schwab F & Ames CP. Impact of age on the likelihood of reaching a minimum clinically important difference in 374 three-column spinal osteotomies: clinical article. J. Neurosurg. Spine 20, 306–12 (2014).

57.        Slobodyanyuk K; Poorman CE; Smith JS; Protopsaltis TS; Hostin R; Bess S; Mundis GM; Schwab FJ & Lafage V. Clinical improvement through nonoperative treatment of adult spinal deformity: who is likely to benefit? Neurosurg. Focus 36, E2 (2014).

58.        Smith JS; Lafage V; Schwab FJ; Shaffrey CI; Protopsaltis T; Klineberg E; Gupta M; Scheer JK; Fu K-MG; Mundis G; Hostin R; Deviren V; Hart R; Burton DC; Bess S & Ames CP. Prevalence and Type of Cervical Deformity Among 470 Adults With Throacolumbar Deformity. Spine (Phila. Pa. 1976). 39, E1001–9 (2014).

59.        Smith JS; Shaffrey E; Klineberg E; Shaffrey CI; Lafage V; Schwab FJ; Protopsaltis T; Scheer JK; Mundis GM; Fu K-MG; Gupta MC; Hostin R; Deviren V; Kebaish K; Hart R; Burton DC; Line B; Bess S; et al. Prospective multicenter assessment of risk factors for rod fracture following surgery for adult spinal deformity. J. Neurosurg. Spine 21, 994–1003 (2014).

60.        Smith JS; Singh M; Klineberg E; Shaffrey CI; Lafage V; Schwab FJ; Protopsaltis T; Ibrahimi D; Scheer JK; Mundis G; Gupta MC; Hostin R; Deviren V; Kebaish K; Hart R; Burton DC; Bess S & Ames CP. Surgical treatment of pathological loss of lumbar lordosis (flatback) in patients with normal sagittal vertical axis achieves similar clinical improvement as surgical treatment of elevated sagittal vertical axis. J. Neurosurg. Spine 1–11 (2014). doi:10.3171/2014.3.SPINE13580

61.        Sparrey CJ; Bailey JF; Safaee M; Clark AJ; Lafage V; Schwab F; Smith JS & Ames CP. Etiology of lumbar lordosis and its pathophysiology: a review of the evolution of lumbar lordosis, and the mechanics and biology of lumbar degeneration. Neurosurg. Focus 36, E1 (2014).

62.        Uribe JS; Deukmedjian AR; Mummaneni P V; Fu K-MG; Mundis GM; Okonkwo DO; Kanter AS; Eastlack R; Wang MY; Anand N; Fessler RG; La Marca F; Park P; Lafage V; Deviren V; Bess S & Shaffrey CI. Complications in adult spinal deformity surgery: an analysis of minimally invasive, hybrid, and open surgical techniques. Neurosurg. Focus 36, E15 (2014).

63.        Wang MY; Mummaneni P V; Fu K-MG; Anand N; Okonkwo DO; Kanter AS; La Marca F; Fessler R; Uribe J; Shaffrey CI; Lafage V; Haque RM; Deviren V & Mundis GM. Less invasive surgery for treating adult spinal deformities: ceiling effects for deformity correction with 3 different techniques. Neurosurg. Focus 36, E12 (2014).

64.        Ames CP; Smith JS; Eastlack R; Blaskiewicz DJ; Shaffrey CI; Schwab F; Bess S; Kim HJ; Mundis GM; Klineberg E; Gupta M; O’Brien M; Hostin R; Scheer JK; Protopsaltis TS; Fu KG; Hart R; Albert TJ; et al. Reliability assessment of a novel cervical spine deformity classification system. J. Neurosurg. Spine 23, 673–83 (2015).

65.        Ames C; Gammal I; Matsumoto M; Hosogane N; Smith JS; Protopsaltis T; Yamato Y; Matsuyama Y; Taneichi H; Lafage R; Ferrero E; Schwab FJ & Lafage V. Geographic and Ethnic Variations in Radiographic Disability Thresholds: Analysis of North American and Japanese Operative Adult Spinal Deformity Populations. Neurosurgery 0, 1 (2015).

66.        Buckland AJ; Vigdorchik J; Schwab FJ; Errico TJ; Lafage R; Ames C; Bess S; Smith J; Mundis GM & Lafage V. Acetabular Anteversion Changes Due to Spinal Deformity Correction: Bridging the Gap Between Hip and Spine Surgeons. J. Bone Joint Surg. Am. 97, 1913–20 (2015).

67.        Daniels AH; Smith JS; Hiratzka J; Ames CP; Bess S; Shaffrey CI; Schwab FJ; Lafage V; Klineberg EO; Burton D; Mundis GM; Line B; Hart RA & International Spine Study Group (ISSG). Functional Limitations Due to Lumbar Stiffness in Adults With and Without Spinal Deformity. Spine (Phila. Pa. 1976). 40, 1599–604 (2015).

68.        Fakurnejad S; Scheer JK; Lafage V; Smith JS; Deviren V; Hostin R; Mundis GM; Burton DC; Klineberg E; Gupta M; Kebaish K; Shaffrey CI; Bess S; Schwab F; Ames CP & International Spine Study Group. The likelihood of reaching minimum clinically important difference and substantial clinical benefit at 2 years following a 3-column osteotomy: analysis of 140 patients. J. Neurosurg. Spine 23, 1–9 (2015).

69.        Ferrero E; Vira S; Ames CP; Kebaish K; Obeid I; O’Brien MF; Gupta MC; Boachie-Adjei O; Smith JS; Mundis GM; Challier V; Protopsaltis TS; Schwab FJ; Lafage V & International Spine Study Group. Analysis of an unexplored group of sagittal deformity patients: low pelvic tilt despite positive sagittal malalignment. Eur. Spine J. (2015). doi:10.1007/s00586-015-4048-1

70.        Gupta, Munish C. MD*; Ferrero, Emmanuelle MD†; Mundis, Gregory MD‡; Smith, Justin S. MD, PhD§; Shaffrey, Christopher I. MD§; Schwab, Frank MD†; Kim, Han Jo MD¶; Boachie-Adjei, Oheneba MD¶; Lafage, Virginie PhD†; Bess, Shay MD||; Hostin, Richard MD**; Burt EMISSG. Pedicle Subtraction Osteotomy in the Revision Versus Primary Adult Spinal Deformity Patient: Is There a Difference in Correction and Complications? Spine (Phila. Pa. 1976). 40, E1169–E1175 (2015).

71.        Klineberg EO; Passias PG; Jalai CM; Worley N; Sciubba DM; Burton DC; Gupta MC; Soroceanu A; Zebala LP; Mundis GM; Kim HJ; Hamilton DK; Hart RA; Ames CP; Lafage V & International Spine Study Group. Predicting Extended Length of Hospital Stay in an Adult Spinal Deformity Surgical Population. Spine (Phila. Pa. 1976). (2015). doi:10.1097/BRS.0000000000001391

72.        Liu S; Lafage R; Smith JS; Protopsaltis TS; Lafage VC; Challier V; Shaffrey CI; Radcliff K; Arnold PM; Chapman JR; Schwab FJ; Massicotte EM; Yoon ST; Fehlings MG & Ames CP. Impact of dynamic alignment, motion, and center of rotation on myelopathy grade and regional disability in cervical spondylotic myelopathy. J. Neurosurg. Spine 23, 690–700 (2015).

73.        Liu S; Tetreault L; Fehlings MG; Challier V; Smith JS; Shaffrey CI; Arnold PM; Scheer JK; Chapman JR; Kopjar B; Protopsaltis TS; Lafage V; Schwab F; Massicotte EM; Yoon ST & Ames CP. Novel Method Using Baseline Normalization and Area Under the Curve to Evaluate Differences in Outcome Between Treatment Groups and Application to Patients With Cervical Spondylotic Myelopathy Undergoing Anterior Versus Posterior Surgery. Spine (Phila. Pa. 1976). 40, E1299–E1304 (2015).

74.        Moal B; Lafage V; Smith JS; Ames CP; Mundis G; Terran JS; Klineberg E; Hart R; Boachie-Adjei O; Bess S; Skalli W & Schwab F. Clinical Improvement Through Surgery for Adult Spinal Deformity: What Can Be Expected and Who Is Likely to Benefit Most? Spine Deform. 3, 566–574 (2015).

75.        Oh T; Scheer JK; Eastlack R; Smith JS; Lafage V; Protopsaltis TS; Klineberg E; Passias PG; Deviren V; Hostin R; Gupta M; Bess S; Schwab F; Shaffrey CI & Ames CP. Cervical compensatory alignment changes following correction of adult thoracic deformity: a multicenter experience in 57 patients with a 2-year follow-up. J. Neurosurg. Spine 1–8 (2015). doi:10.3171/2014.10.SPINE14829

76.        Park P; Wang MY; Lafage V; Nguyen S; Ziewacz J; Okonkwo DO; Uribe JS; Eastlack RK; Anand N; Haque R; Fessler RG; Kanter AS; Deviren V; La Marca F; Smith JS; Shaffrey CI; Mundis GM & Mummaneni P V. Comparison of two minimally invasive surgery strategies to treat adult spinal deformity. J. Neurosurg. Spine 22, 374–380 (2015).

77.        Park P; Wang MY; Nguyen S; Mundis GM; La Marca F; Uribe JS; Anand N; Okonkwo DO; Kanter AS; Fessler R; Eastlack RK; Chou D; Deviren V; Nunley PD; Shaffrey CI & Mummaneni P V. Comparison of Complications and Clinical and Radiographic Outcomes Between Non-Obese and Obese Patients With Adult Spinal Deformity Undergoing Minimally Invasive Surgery. World Neurosurg. 87, 55–60 (2015).

78.        Passias PG; Soroceanu A; Smith J; Boniello A; Yang S; Scheer JK; Schwab F; Shaffrey C; Kim HJ; Protopsaltis T; Mundis G; Gupta M; Klineberg E; Lafage V & Ames C. Postoperative Cervical Deformity in 215 Thoracolumbar Patients With Adult Spinal Deformity. Spine (Phila. Pa. 1976). 40, 283–291 (2015).

79.        Passias PG; Soroceanu A; Scheer J; Yang S; Boniello A; Smith JS; Protopsaltis T; Kim HJ; Schwab F; Gupta M; Klineberg E; Mundis G; Lafage R; Hart R; Shaffrey C; Lafage V & Ames C. Magnitude of Preoperative Cervical Lordotic Compensation and C2-T3 Angle are Correlated to Increased Risk of Post-operative Sagittal Spinal Pelvic Malalignment in Adult Thoracolumbar Deformity Patients at 2-year Follow-up. Spine J. (2015). doi:10.1016/j.spinee.2015.04.007

80.        Protopsaltis TS; Scheer JK; Terran JS; Smith JS; Hamilton DK; Kim HJ; Mundis GM; Hart RA; McCarthy IM; Klineberg E; Lafage V; Bess S; Schwab F; Shaffrey CI; Ames CP & International Spine Study Group. How the neck affects the back: changes in regional cervical sagittal alignment correlate to HRQOL improvement in adult thoracolumbar deformity patients at 2-year follow-up. J. Neurosurg. Spine 23, 153–8 (2015).

81.        Saigal R; Clark AJ; Scheer JK; Smith JS; Bess S; Mummaneni P V; McCarthy IM; Hart RA; Kebaish KM; Klineberg EO; Deviren V; Schwab F; Shaffrey CI & Ames CP. Adult Deformity Surgery (ASD) Patients Recall Fewer than 50% of the Risks Discussed in the Informed Consent Process Preoperatively and the Recall Rate Worsens Significantly in the Postoperative Period. Spine (Phila. Pa. 1976). (2015). doi:10.1097/BRS.0000000000000964

82.        Scheer JK; Mundis GM; Klineberg E; Hart R a.; Deviren V; Nguyen S; Protopsaltis TS; Gupta M; Bess S; Shaffrey CI; Schwab F; Lafage V; Smith JS & Ames CP. Postoperative Recovery After Adult Spinal Deformity Surgery. Spine (Phila. Pa. 1976). 40, 1505–1515 (2015).

83.        Scheer JK; Passias PG; Sorocean AM; Boniello AJ; Mundis GM; Klineberg E; Kim HJ; Protopsaltis TS; Gupta M; Bess S; Shaffrey CI; Schwab F; Lafage V; Smith JS & Ames CP. Association between preoperative cervical sagittal deformity and inferior outcomes at 2-year follow-up in patients with adult thoracolumbar deformity: analysis of 182 patients. J. Neurosurg. Spine 24, 1–8 (2015).

84.        Scheer JK; Smith JS; Clark AJ; Lafage V; Kim HJ; Rolston JD; Eastlack R; Hart RA; Protopsaltis TS; Kelly MP; Kebaish K; Gupta M; Klineberg E; Hostin R; Shaffrey CI; Schwab F & Ames CP. Comprehensive study of back and leg pain improvements after adult spinal deformity surgery: analysis of 421 patients with 2-year follow-up and of the impact of the surgery on treatment satisfaction. J. Neurosurg. Spine 1–14 (2015). doi:10.3171/2014.10.SPINE14475

85.        Scheer JK; Mundis GM; Klineberg E; Hart RA; Deviren V; Burton DC; Protopsaltis TS; Gupta M; Rolston JD; Bess S; Shaffrey CI; Schwab F; Lafage V; Smith JS & Ames CP. Recovery following adult spinal deformity surgery: the effect of complications and reoperation in 149 patients with 2-year follow-up. Eur. Spine J. (2015). doi:10.1007/s00586-015-3787-3

86.        Sciubba DM; Yurter A; Smith JS; Kelly MP; Scheer JK; Goodwin CR; Lafage V; Hart RA; Bess S; Kebaish K; Schwab F; Shaffrey CI & Ames CP. A Comprehensive Review of Complication Rates after Surgery for Adult Deformity: A Reference for Informed Consent. Spine Deform. 3, 575–594 (2015).

87.        Sciubba DM; Scheer JK; Smith JS; Lafage V; Klineberg E; Gupta M; Mundis GM; Protopsaltis TS; Kim HJ; Hiratzka JR; Koski T; Shaffrey CI; Bess S; Hart RA & Ames CP. Which Daily Functions Are Most Affected by Stiffness Following Total Lumbar Fusion: Comparison of Upper Thoracic and Thoracolumbar Proximal Endpoints. Spine (Phila. Pa. 1976). (2015). doi:10.1097/BRS.0000000000000968

88.        Sciubba DM; Scheer JK; Yurter A; Smith JS; Lafage V; Klineberg E; Gupta M; Eastlack R; Mundis GM; Protopsaltis TS; Blaskiewicz D; Kim HJ; Koski T; Kebaish K; Shaffrey CI; Bess S; Hart RA; Schwab F; et al. Patients with spinal deformity over the age of 75: a retrospective analysis of operative versus non-operative management. Eur. Spine J. (2015). doi:10.1007/s00586-015-3759-7

89.        Smith JS; Lafage V; Shaffrey CI; Schwab F; Lafage R; Hostin R; OʼBrien M; Boachie-Adjei O; Akbarnia BA; Mundis GM; Errico T; Kim HJ; Protopsaltis TS; Hamilton DK; Scheer JK; Sciubba D; Ailon T; Fu K-MG; et al. Outcomes of Operative and Nonoperative Treatment for Adult Spinal Deformity: A Prospective, Multicenter, Propensity-Matched Cohort Assessment With Minimum 2-Year Follow-up. Neurosurgery 0, 1 (2015).

90.        Smith JS; Ramchandran S; Lafage V; Shaffrey CI; Ailon T; Klineberg E; Protopsaltis T; Schwab FJ; OʼBrien M; Hostin R; Gupta M; Mundis G; Hart R; Kim HJ; Passias P; Scheer JK; Deviren V; Burton DC; et al. Prospective Multicenter Assessment of Early Complication Rates Associated With Adult Cervical Deformity Surgery in 78 Patients. Neurosurgery 0, 1–11 (2015).

91.        Smith JS; Shaffrey CI; Lafage V; Schwab F; Scheer JK; Protopsaltis T; Klineberg E; Gupta M; Hostin R; Fu K-MG; Mundis GM; Kim HJ; Deviren V; Soroceanu A; Hart RA; Burton DC; Bess S; Ames CP; et al. Comparison of best versus worst clinical outcomes for adult spinal deformity surgery: a retrospective review of a prospectively collected, multicenter database with 2-year follow-up. J. Neurosurg. Spine 23, 349–59 (2015).

92.        Soroceanu A; Burton DC; Diebo BG; Smith JS; Hostin R; Shaffrey CI; Boachie-Adjei O; Mundis GM; Ames C; Errico TJ; Bess S; Gupta MC; Hart RA; Schwab FJ; Lafage V & International Spine Study Group. Impact of obesity on complications, infection, and patient-reported outcomes in adult spinal deformity surgery. J. Neurosurg. Spine 23, 1–9 (2015).

93.        Soroceanu A; Diebo BG; Burton D; Smith JS; Deviren V; Shaffrey C; Kim HJ; Mundis G; Ames C; Errico T; Bess S; Hostin R; Hart R; Schwab F; Lafage V & International Spine Study Group. Radiographical and Implant-Related Complications in Adult Spinal Deformity Surgery: Incidence, Patient Risk Factors, and Impact on Health-Related Quality of Life. Spine (Phila. Pa. 1976). 40, 1414–21 (2015).

94.        Bess S; Line B; Fu K-M; McCarthy I; Lafage V; Schwab F; Shaffrey C; Ames C; Akbarnia B; Jo H; Kelly M; Burton D; Hart R; Klineberg E; Kebaish K; Hostin R; Mundis G; Mummaneni P; et al. The Health Impact of Symptomatic Adult Spinal Deformity: Comparison of Deformity Types to United States Population Norms and Chronic Diseases. Spine (Phila. Pa. 1976). 41, 224–33 (2016).

95.        Bess S; Protopsaltis TS; Lafage V; Lafage R; Ames CP; Errico T; Smith JS & International Spine Study Group. Clinical and Radiographic Evaluation of Adult Spinal Deformity. Clin. spine Surg. 29, 6–16 (2016).

96.        Diebo BG; Lafage R; Ames CP; Bess S; Obeid I; Klineberg E; Cunningham ME; Smith JS; Hostin R; Liu S; Passias PG; Schwab FJ; Lafage V & International Spine Study Group. Ratio of lumbar 3-column osteotomy closure: patient-specific deformity characteristics and level of resection impact correction of truncal versus pelvic compensation. Eur. Spine J. (2016). doi:10.1007/s00586-016-4533-1

97.        Gupta M; Henry JK; Schwab F; Klineberg E; Smith JS; Gum J; Polly DW; Liabaud B; Diebo BG; Hamilton DK; Eastlack R; Passias PG; Burton D; Protopsaltis T; Lafage V & International Spine Study Group. Dedicated Spine Measurement Software Quantifies Key Spino-Pelvic Parameters More Reliably Than Traditional Picture Archiving and Communication Systems Tools. Spine (Phila. Pa. 1976). 41, E22–7 (2016).

98.        Hamilton DK; Kanter AS; Bolinger BD; Mundis GM; Nguyen S; Mummaneni P V.; Anand N; Fessler RG; Passias PG; Park P; La Marca F; Uribe JS; Wang MY; Akbarnia BA; Shaffrey CI; Okonkwo DO & International Spine Study Group (ISSG). Reoperation rates in minimally invasive, hybrid and open surgical treatment for adult spinal deformity with minimum 2-year follow-up. Eur. Spine J. (2016). doi:10.1007/s00586-016-4443-2

99.        Jain A; Lafage V; Kelly MP; Hassanzadeh H; Neuman BJ; Sciubba DM; Bess S; Shaffrey CI; Ames CP; Scheer JK; Burton D; Gupta MC; Hart R; Hostin RA; Kebaish KM & International Spine Study Group. Validity, Reliability, and Responsiveness of SRS-7 as an Outcomes Assessment Instrument for Operatively Treated Patients with Adult Spinal Deformity. Spine (Phila. Pa. 1976). 1–10 (2016). doi:10.1097/BRS.0000000000001540

100.      Jalai CM; Passias PG; Lafage V; Smith JS; Lafage R; Poorman GW; Diebo B; Liabaud B; Neuman BJ; Scheer JK; Shaffrey CI; Bess S; Schwab F; Ames CP & International Spine Study Group (ISSG). A comparative analysis of the prevalence and characteristics of cervical malalignment in adults presenting with thoracolumbar spine deformity based on variations in treatment approach over 2 years. Eur. Spine J. (2016). doi:10.1007/s00586-016-4564-7

101.      Kelly MP; Zebala LP; Kim HJ; Sciubba DM; Smith JS; Shaffrey CI; Bess S; Klineberg E; Mundis G; Burton D; Hart R; Soroceanu A; Schwab F; Lafage V & International Spine Study Group. Effectiveness of preoperative autologous blood donation for protection against allogeneic blood exposure in adult spinal deformity surgeries: a propensity-matched cohort analysis. J. Neurosurg. Spine 24, 124–30 (2016).

102.      Lafage R; Schwab F; Challier V; Henry JK; Gum J; Smith J; Hostin R; Shaffrey C; Kim HJ; Ames C; Scheer J; Klineberg E; Bess S; Burton D; Lafage V & International Spine Study Group. Defining Spino-Pelvic Alignment Thresholds: Should Operative Goals in Adult Spinal Deformity Surgery Account for Age? Spine (Phila. Pa. 1976). 41, 62–8 (2016).

103.      Lau D; Funao H; Clark AJ; Nicholls F; Smith J; Bess S; Shaffrey C; Schwab FJ; Lafage V; Deviren V; Hart R; Kebaish KM; Ames CP & International Spine Study Group. The Clinical Correlation of the Hart-ISSG Proximal Junctional Kyphosis Severity Scale With Health-Related Quality-of-life Outcomes and Need for Revision Surgery. Spine (Phila. Pa. 1976). 41, 213–23 (2016).

104.      Liu S; Diebo BG; Henry JK; Smith JS; Hostin R; Cunningham ME; Mundis G; Ames CP; Burton D; Bess S; Akbarnia B; Hart R; Passias PG; Schwab FJ; Lafage V & International Spine Study Group (ISSG). The benefit of nonoperative treatment for adult spinal deformity: identifying predictors for reaching a minimal clinically important difference. Spine J. 16, 210–8 (2016).

105.      Mummaneni P V; Park P; Fu K-M; Wang MY; Nguyen S; Lafage V; Uribe JS; Ziewacz J; Terran J; Okonkwo DO; Anand N; Fessler R; Kanter AS; LaMarca F; Deviren V; Bess RS; Schwab FJ; Smith JS; et al. Does Minimally Invasive Percutaneous Posterior Instrumentation Reduce Risk of Proximal Junctional Kyphosis in Adult Spinal Deformity Surgery? A Propensity-Matched Cohort Analysis. Neurosurgery 78, 101–8 (2016).

106.      Park P; Okonkwo DO; Nguyen S; Mundis GM; Than KD; Deviren V; La Marca F; Fu K-M; Wang MY; Uribe JS; Anand N; Fessler R; Nunley PD; Chou D; Kanter AS; Shaffrey CI; Akbarnia BA; Passias PG; et al. Can a Minimal Clinically Important Difference Be Achieved in Elderly Patients with Adult Spinal Deformity Who Undergo Minimally Invasive Spinal Surgery? World Neurosurg. 86, 168–72 (2016).

107.      Passias PG; Klineberg EO; Jalai CM; Worley N; Poorman GW; Line B; Oh C; Burton DC; Kim HJ; Sciubba DM; Hamilton DK; Ames CP; Smith JS; Shaffrey CI; Lafage V & Bess S. Hospital Readmission within Two Years Following Adult Thoracolumbar Spinal Deformity Surgery: Prevalence, Predictors, and Effect on Patient-Derived Outcome Measures. Spine (Phila. Pa. 1976). 1–10 (2016). doi:10.1097/BRS.0000000000001552

108.      Passias PG; Oh C; Jalai CM; Worley N; Lafage R; Scheer JK; Klineberg EO; Hart RA; Kim HJ; Smith JS; Lafage V; Ames CP & International Spine Study Group (ISSG). Predictive Model for Cervical Alignment and Malalignment Following Surgical Correction of Adult Spinal Deformity. Spine (Phila. Pa. 1976). 1–10 (2016). doi:10.1097/BRS.0000000000001640

109.      Passias PG; Soroceanu A; Yang S; Schwab F; Ames C; Boniello A; Smith J; Shaffrey C; Boachie-Adjei O; Mundis G; Burton D; Klineberg E; Hart R; Hamilton DK; Sciubba DM; Bess S & Lafage V. Predictors of Revision Surgical Procedure Excluding Wound Complications in Adult Spinal Deformity and Impact on Patient-Reported Outcomes and Satisfaction: A Two-Year Follow-up. J. Bone Joint Surg. Am. 98, 536–43 (2016).

110.      Ramchandran S; Smith JS; Ailon T; Klineberg E; Shaffrey C; Lafage V; Schwab F; Bess S; Daniels A; Scheer JK; Protopsaltis TS; Arnold P; Haid RW; Chapman J; Fehlings MG; Ames CP & AOSpine North America ISSG. Assessment of Impact of Long-Cassette Standing X-Rays on Surgical Planning for Cervical Pathology: An International Survey of Spine Surgeons. Neurosurgery 78, 717–24 (2016).

111.      Scheer JK; Osorio JA; Smith JS; Schwab F; Lafage V; Hart RA; Bess S; Line B; Diebo BG; Protopsaltis TS; Jain A; Ailon T; Burton DC; Shaffrey CI; Klineberg E; Ames CP & and the International Spine Study Group. Development of Validated Computer Based Pre-operative Predictive Model for Proximal Junction Failure (PJF) or Clinically Significant PJK with 86% Accuracy Based on 510 ASD Patients with 2-year Follow-up. Spine (Phila. Pa. 1976). 1–10 (2016). doi:10.1097/BRS.0000000000001598

112.      Smith JS; Klineberg E; Shaffrey CI; Lafage V; Schwab FJ; Protopsaltis T; Scheer JK; Ailon T; Ramachandran S; Daniels A; Mundis G; Gupta M; Hostin R; Deviren V; Eastlack R; Passias P; Hamilton DK; Hart R; et al. Assessment of Surgical Treatment Strategies for Moderate to Severe Cervical Spinal Deformity Reveals Marked Variation in Approaches, Osteotomies and Fusion Levels. World Neurosurg. 91, 228–237 (2016).

113.      Smith JS; Klineberg E; Lafage V; Shaffrey CI; Schwab F; Lafage R; Hostin R; Mundis GM; Errico TJ; Kim HJ; Protopsaltis TS; Hamilton DK; Scheer JK; Soroceanu A; Kelly MP; Line B; Gupta M; Deviren V; et al. Prospective multicenter assessment of perioperative and minimum 2-year postoperative complication rates associated with adult spinal deformity surgery. J. Neurosurg. Spine 1–14 (2016). doi:10.3171/2015.11.SPINE151036

114.      Soroceanu A; Burton DC; Oren JH; Smith JS; Hostin R; Shaffrey CI; Akbarnia BA; Ames CP; Errico TJ; Bess S; Gupta MC; Deviren V; Schwab FJ; Lafage V & International Spine Study Group. Medical Complications after Adult Spinal Deformity Surgery: Incidence, Risk factors, and Clinical Impact. Spine (Phila. Pa. 1976). 18, 345–52 (2016).

115.      Than KD; Park P; Fu K; Nguyen S; Wang MY; Chou D; Nunley PD; Anand N; Fessler RG; Shaffrey CI; Bess S; Akbarnia BA; Deviren V; Uribe JS; La Marca F; Kanter AS; Okonkwo DO; Mundis GM; et al. Clinical and radiographic parameters associated with best versus worst clinical outcomes in minimally invasive spinal deformity surgery. J. Neurosurg. Spine 1–5 (2016). doi:10.3171/2015.12.SPINE15999

116.      Theologis AA; Ailon T; Scheer JK; Smith JS; Shaffrey CI; Bess S; Gupta M; Klineberg EO; Kebaish K; Schwab F; Lafage V; Burton D; Hart R; Ames CP & International Spine Study Group. Impact of preoperative depression on 2-year clinical outcomes following adult spinal deformity surgery: the importance of risk stratification based on type of psychological distress. J. Neurosurg. Spine 1–9 (2016). doi:10.3171/2016.2.SPINE15980

 

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